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Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model
Joint Authors
Seong, Myeongsu
Myoung, NoSoung
Lee, Songhyun
Jeong, Hyeryun
Yim, Sang-Youp
Kim, Jae Gwan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques.
In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes.
We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis.
Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette.
Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner.
Our results showed that the treatment causes variations of biochemical compositions in the skin.
For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.
American Psychological Association (APA)
Seong, Myeongsu& Myoung, NoSoung& Lee, Songhyun& Jeong, Hyeryun& Yim, Sang-Youp& Kim, Jae Gwan. 2017. Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model. Journal of Spectroscopy،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187810
Modern Language Association (MLA)
Seong, Myeongsu…[et al.]. Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model. Journal of Spectroscopy No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1187810
American Medical Association (AMA)
Seong, Myeongsu& Myoung, NoSoung& Lee, Songhyun& Jeong, Hyeryun& Yim, Sang-Youp& Kim, Jae Gwan. Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model. Journal of Spectroscopy. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187810