One-Year Clinical Outcome of Inspiron Stent in All-Comers Population (Analysis from 790 Consecutive Patients)‎

Abstract EN

Aims.

The goal of this study was to evaluate the performance of the InspironTM coronary stent (Scitech Medical™, Goiás, Brazil).

The InspironTM sirolimus-eluting stent uses an ultrathin L-605 cobalt-chromium alloy with a 75 μm strut thickness platform coated with an abluminal biodegradable polymer.

The polymer is eliminated from the body through the tricarboxylic acid cycle in 6–9 months, releasing 80% of the drug within 30 days after its deployment.

Methods.

It was a prospective, single-center registry.

To represent clinical practice, all patients undergoing percutaneous coronary intervention were included in this registry.

There were no exclusion criteria.

Clinical follow-ups were performed at twelve months.

The endpoints were the occurrence of all-cause death, definite stent thrombosis, and new revascularization.

Results.

Between November 2017 and May 2019, 790 patients were included (1067 lesions).

The mean age was 60.42 ± 14.94 years, and 74.7% presented with acute coronary syndrome.

Diabetes mellitus was present in 43.9% of patients, and previous myocardial infarction and previous percutaneous coronary intervention were present in 17.9% and 11.3%, respectively.

Angiographic success was achieved in 99.1%.

The incidence of all-cause death was 11.5% (6.2% in-hospital and 5.3% in the follow-up) and definitive stent thrombosis was 0.2%.

New revascularization was performed in only 5.8% (target lesion revascularization: 2.2%; progression of disease in another lesion: 3.6%).

Based on the multivariate regression analysis, only chronic renal failure was an independent predictor of adverse events (OR: 3.3; 95% CI: 1.22–8.92).

Conclusion.

The result of this single-center registry demonstrates the safety and excellent performance of the InspironTM stent in daily clinical practice with a low rate of adverse cardiac events.