Spectroscopic Characterization of Omeprazole and Its Salts
Joint Authors
Vrbanec, Tomislav
Šket, Primož
Merzel, Franci
Smrkolj, Matej
Grdadolnik, Jože
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
During drug development, it is important to have a suitable crystalline form of the active pharmaceutical ingredient (API).
Mostly, the basic options originate in the form of free base, acid, or salt.
Substances that are stable only within a certain pH range are a challenge for the formulation.
For the prazoles, which are known to be sensitive to degradation in an acid environment, the formulation is stabilized with alkaline additives or with the application of API formulated as basic salts.
Therefore, preparation and characterization of basic salts are needed to monitor any possible salinization of free molecules.
We synthesized salts of omeprazole from the group of alkali metals (Li, Na, and K) and alkaline earth metals (Mg, Ca).
The purpose of the presented work is to demonstrate the applicability of vibrational spectroscopy to discriminate between the OMP and OMP-salt molecules.
For this reason, the physicochemical properties of 5 salts were probed using infrared and Raman spectroscopy, NMR, TG, DSC, and theoretical calculation of vibrational frequencies.
We found out that vibrational spectroscopy serves as an applicable spectroscopic tool which enables an accurate, quick, and nondestructive way to determine the characteristic of OMP and its salts.
American Psychological Association (APA)
Vrbanec, Tomislav& Šket, Primož& Merzel, Franci& Smrkolj, Matej& Grdadolnik, Jože. 2017. Spectroscopic Characterization of Omeprazole and Its Salts. Journal of Spectroscopy،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1187844
Modern Language Association (MLA)
Vrbanec, Tomislav…[et al.]. Spectroscopic Characterization of Omeprazole and Its Salts. Journal of Spectroscopy No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1187844
American Medical Association (AMA)
Vrbanec, Tomislav& Šket, Primož& Merzel, Franci& Smrkolj, Matej& Grdadolnik, Jože. Spectroscopic Characterization of Omeprazole and Its Salts. Journal of Spectroscopy. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1187844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187844