Shot-Noise Limited Time-Encoded Raman Spectroscopy
Joint Authors
Huber, Robert
Karpf, Sebastian
Eibl, Matthias
Wieser, Wolfgang
Klein, Thomas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Raman scattering, an inelastic scattering mechanism, provides information about molecular excitation energies and can be used to identify chemical compounds.
Albeit being a powerful analysis tool, especially for label-free biomedical imaging with molecular contrast, it suffers from inherently low signal levels.
This practical limitation can be overcome by nonlinear enhancement techniques like stimulated Raman scattering (SRS).
In SRS, an additional light source stimulates the Raman scattering process.
This can lead to orders of magnitude increase in signal levels and hence faster acquisition in biomedical imaging.
However, achieving a broad spectral coverage in SRS is technically challenging and the signal is no longer background-free, as either stimulated Raman gain (SRG) or loss (SRL) is measured, turning a sensitivity limit into a dynamic range limit.
Thus, the signal has to be isolated from the laser background light, requiring elaborate methods for minimizing detection noise.
Here, we analyze the detection sensitivity of a shot-noise limited broadband stimulated time-encoded Raman (TICO-Raman) system in detail.
In time-encoded Raman, a wavelength-swept Fourier domain mode locking (FDML) laser covers a broad range of Raman transition energies while allowing a dual-balanced detection for lowering the detection noise to the fundamental shot-noise limit.
American Psychological Association (APA)
Karpf, Sebastian& Eibl, Matthias& Wieser, Wolfgang& Klein, Thomas& Huber, Robert. 2017. Shot-Noise Limited Time-Encoded Raman Spectroscopy. Journal of Spectroscopy،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1187877
Modern Language Association (MLA)
Karpf, Sebastian…[et al.]. Shot-Noise Limited Time-Encoded Raman Spectroscopy. Journal of Spectroscopy No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1187877
American Medical Association (AMA)
Karpf, Sebastian& Eibl, Matthias& Wieser, Wolfgang& Klein, Thomas& Huber, Robert. Shot-Noise Limited Time-Encoded Raman Spectroscopy. Journal of Spectroscopy. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1187877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187877