Comparison of Two Percutaneous Atrial Septal Defect Occluders for Device Healing and Nickel Release in a Chronic Porcine Model
Joint Authors
Jalal, Zakaria
Boudjemline, Younes
Iriart, Xavier
Seguela, Pierre-Emmanuel
Delmond, Samantha
Loyer, Virgine
Gonthier, David
Bernus, Olivier
Durand, Marlène
Bordenave, Laurence
Thambo, Jean-Benoit
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To investigate the healing process and nickel release of the Hyperion occluder (Comed BV, Netherlands), as compared to the Amplatzer septal occluder (ASO) (St.
Jude Medical Inc., St.
Paul, MN, USA) in a chronic swine model.
Background.
Some long-term complications occurring after percutaneous atrial septal defect (ASD) closure may be partially associated with an inappropriate healing of the device and increased nickel release.
There is no direct comparative study of different occluders for healing and nickel release.
Methods.
After percutaneous ASD creation, 12 pigs were implanted with 15 mm Hyperion (n = 6) and 15 mm ASO (n = 6) devices.
After 1 month (n = 3 for each device) and 3 months (n = 3 for each device) of follow-up, device explantation was performed and healing was assessed using histopathological workup.
Systemic and tissular nickel release was performed.
Results.
Implantation was successful in 100% without complications.
Device coverage was observed as early as 1 month after implantation and was almost complete after 3 months.
A granulation tissue with a predominantly mononuclear inflammatory reaction was observed in contact with nitinol wires while an inflammatory reaction was seen in contact with textile fibers.
We found no statistically significant difference between the 2 devices whether for histological grading scores or systemic nickel release, regardless to follow-up duration.
Conclusions.
In this preclinical study, we demonstrated that Amplatzer septal occluder and Hyperion occluder were not significantly different for device healing and nickel release processes.
American Psychological Association (APA)
Jalal, Zakaria& Boudjemline, Younes& Iriart, Xavier& Seguela, Pierre-Emmanuel& Delmond, Samantha& Loyer, Virgine…[et al.]. 2020. Comparison of Two Percutaneous Atrial Septal Defect Occluders for Device Healing and Nickel Release in a Chronic Porcine Model. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187880
Modern Language Association (MLA)
Jalal, Zakaria…[et al.]. Comparison of Two Percutaneous Atrial Septal Defect Occluders for Device Healing and Nickel Release in a Chronic Porcine Model. Journal of Interventional Cardiology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1187880
American Medical Association (AMA)
Jalal, Zakaria& Boudjemline, Younes& Iriart, Xavier& Seguela, Pierre-Emmanuel& Delmond, Samantha& Loyer, Virgine…[et al.]. Comparison of Two Percutaneous Atrial Septal Defect Occluders for Device Healing and Nickel Release in a Chronic Porcine Model. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1187880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187880