Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry
Joint Authors
Oh, Gyu Chul
Park, Kyung Woo
Kang, Jeehoon
Han, Jung-Kyu
Yang, Han-Mo
Kang, Hyun-Jae
Koo, Bon Kwon
Kim, Hyo-Soo
Source
Journal of Interventional Cardiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Objectives.
In most bifurcation lesions, keeping the procedure simple by not treating the side-branch (SB) lesion when possible is considered the best method.
However, because of improvements with 2nd generation drug-eluting stents (DESs), it remains unknown whether treatment of the SB may improve outcomes in certain subgroups, especially when exclusively using 2nd generation DESs.
We report the outcome of SB treatment in a group of patients exclusively receiving newer generation DES for bifurcation PCI.
Methods.
Patients undergoing PCI to left anterior descending (LAD) bifurcation lesions with contemporary DES were analyzed from a nationwide registry.
Baseline risk was assessed using the Age, Creatinine, and Ejection Fraction (ACEF) score.
Target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization, was assessed at 3 years.
Results.
Among 1,089 patients with LAD bifurcation lesions, 548 (50.3%) patients underwent SB treatment.
The SB treatment group showed a nonsignificant, but numerically lower rate of 3-year TLF (6.6% vs.
9.2%, HR 0.75, 95%CI 0.44–1.28, p = 0.29).
In patients with low pretreatment risk (ACEF<1.22), SB treatment was associated with a lower rate of 3-year TLF (HR 0.43, 95%CI 0.19–0.96, p = 0.04), while no significant difference was observed in patients with high risk (ACEF≥1.22).
The difference in the low risk group was mostly driven by target lesion revascularization (HR 0.24, 95%CI 0.08–0.75, p = 0.01).
Conclusions.
SB treatment for LAD bifurcation lesions showed favorable long-term outcomes compared with main-branch-only intervention, especially in patients with low pretreatment risk.
American Psychological Association (APA)
Oh, Gyu Chul& Park, Kyung Woo& Kang, Jeehoon& Han, Jung-Kyu& Yang, Han-Mo& Kang, Hyun-Jae…[et al.]. 2020. Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry. Journal of Interventional Cardiology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187888
Modern Language Association (MLA)
Oh, Gyu Chul…[et al.]. Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry. Journal of Interventional Cardiology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1187888
American Medical Association (AMA)
Oh, Gyu Chul& Park, Kyung Woo& Kang, Jeehoon& Han, Jung-Kyu& Yang, Han-Mo& Kang, Hyun-Jae…[et al.]. Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry. Journal of Interventional Cardiology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1187888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187888