The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats
Joint Authors
Rodríguez, Verónica M.
Márquez-Ramos, José Abraham
Hernández-Plata, Isela
Díaz-Muñoz, Mauricio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits.
In this work, we repeatedly exposed adult male Sprague-Dawley rats to 6 injections of 100 mg ATR/kg of body weight (for two weeks) and one saline injection two days after ATR administration.
Locomotor activity was assessed for 15 minutes and/or 2 hours after ATR or saline injection and 2 months after the final ATR administration.
The specific binding of [3H]-SCH23390 to D1-DA receptors and that of [3H]-Spiperone to D2-DA receptors in the dorsal and ventral striatum were assessed 2 days and 2 months after ATR treatment.
ATR administration resulted in immediate, short- and long-term hypoactivity and reduced specific binding of [3H]-SCH23390 in the dorsal striatum of rats evaluated 2 months after the last ATR injection.
The specific binding of [3H]-SCH23390 in the ventral striatum and the specific binding of [3H]-Spiperone in the dorsal and ventral striatum remained unchanged at 2 days or 2 months after ATR treatment.
These results, together with previous findings of our group, indicate that the nigrostriatal system is a preferential target for ATR exposure.
American Psychological Association (APA)
Márquez-Ramos, José Abraham& Hernández-Plata, Isela& Díaz-Muñoz, Mauricio& Rodríguez, Verónica M.. 2017. The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats. Journal of Toxicology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187893
Modern Language Association (MLA)
Márquez-Ramos, José Abraham…[et al.]. The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats. Journal of Toxicology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1187893
American Medical Association (AMA)
Márquez-Ramos, José Abraham& Hernández-Plata, Isela& Díaz-Muñoz, Mauricio& Rodríguez, Verónica M.. The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats. Journal of Toxicology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187893