Screening of Pesticides with the Potential of Inducing DSB and Successive Recombinational Repair
Joint Authors
Suárez-Larios, Karen
Salazar-Martínez, Ana-María
Montero-Montoya, Regina D.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A study was realized to ascertain whether eight selected pesticides would induce double strand breaks (DSB) in lymphocyte cultures and whether this damage would induce greater levels of proteins Rad51 participating in homologous recombination or of p-Ku80 participating in nonhomologous end joining.
Only five pesticides were found to induce DSB of which only glyphosate and paraoxon induced a significant increase of p-Ku80 protein, indicating that nonhomologous end joining recombinational DNA repair system would be activated.
The type of gamma-H2AX foci observed was comparable to that induced by etoposide at similar concentrations.
These results are of importance since these effects occurred at low concentrations in the micromolar range, in acute treatments to the cells.
Effects over longer exposures in actual environmental settings are expected to produce cumulative damage if repeated events of recombination take place over time.
American Psychological Association (APA)
Suárez-Larios, Karen& Salazar-Martínez, Ana-María& Montero-Montoya, Regina D.. 2017. Screening of Pesticides with the Potential of Inducing DSB and Successive Recombinational Repair. Journal of Toxicology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187901
Modern Language Association (MLA)
Suárez-Larios, Karen…[et al.]. Screening of Pesticides with the Potential of Inducing DSB and Successive Recombinational Repair. Journal of Toxicology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1187901
American Medical Association (AMA)
Suárez-Larios, Karen& Salazar-Martínez, Ana-María& Montero-Montoya, Regina D.. Screening of Pesticides with the Potential of Inducing DSB and Successive Recombinational Repair. Journal of Toxicology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187901