Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents
Joint Authors
Brandão, Geraldo Célio
Oliveira, Alaíde Braga
Filho, José Dias de Souza
Kroon, Erna Geessien
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method.
All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2).
For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV.
Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4).
The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1.
These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.
American Psychological Association (APA)
Brandão, Geraldo Célio& Kroon, Erna Geessien& Filho, José Dias de Souza& Oliveira, Alaíde Braga. 2017. Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents. Journal of Tropical Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1187940
Modern Language Association (MLA)
Brandão, Geraldo Célio…[et al.]. Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents. Journal of Tropical Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1187940
American Medical Association (AMA)
Brandão, Geraldo Célio& Kroon, Erna Geessien& Filho, José Dias de Souza& Oliveira, Alaíde Braga. Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents. Journal of Tropical Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1187940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187940