Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11
Joint Authors
Sonda, Tolbert
Nazareth, Rebeka
Horumpende, Pius
Ndaro, Arnold
Mollel, Edson
Paul, Eliakim
Athanase, Emmanuel
Chilongola, Jaffu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
A major challenge to malaria vaccine development is identification of protective epitopes and respective protective immune responses.
Objective.
To characterize naturally acquired Immunoglobulin G (IgG) responses to the synthetic peptide AS202.11, a malaria vaccine candidate.
Methodology.
This community based cross-sectional study enrolled 320 participants aged 1 year and above.
Demographic information was recorded through interviews.
Detection of P.
falciparum infection was done by microscopy, malaria rapid diagnostic test, and polymerase chain reaction.
ELISA was used to detect IgG antibody.
Data was analyzed using STATA.
Results.
The overall AS202.11 IgG seropositivity was 78.8% (73.9–82.9).
Seropositivity by age categories was ≤12 years [74.3% (67.4–80.2)], 13–40 years [85.3% (76.5–91.1)], and >40 years [82.6% (68.7–91.1)].
Compared to the ≤ 12-year-old group, aORs for the other groups were 2.22 (1.14–4.32), p=0.019, and 1.87 (0.81–4.35), p=0.143, for the 13–40-year-old and >40-year-old groups, respectively.
The 13–40-year-old group had more seropositive individuals compared to the ≤ 12-year-old group.
Conclusion.
We report a high degree of recognition of AS202.11 by IgG elicited by field P.
falciparum strains, suggesting its close similarity to native P.
falciparum antigens and possible suitability of the peptide as a future malaria vaccine candidate.
American Psychological Association (APA)
Nazareth, Rebeka& Horumpende, Pius& Sonda, Tolbert& Ndaro, Arnold& Mollel, Edson& Paul, Eliakim…[et al.]. 2017. Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11. Journal of Tropical Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187941
Modern Language Association (MLA)
Nazareth, Rebeka…[et al.]. Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11. Journal of Tropical Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1187941
American Medical Association (AMA)
Nazareth, Rebeka& Horumpende, Pius& Sonda, Tolbert& Ndaro, Arnold& Mollel, Edson& Paul, Eliakim…[et al.]. Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11. Journal of Tropical Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187941