Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country
Joint Authors
Mahapatro, Samarendra
Mahilary, Nijwm
Satapathy, Amit Kumar
Das, Rashmi Ranjan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Acute diarrhea is one of the leading causes of childhood mortality, with rotavirus being an important pathogen.
Nitazoxanide, an antiparasitic agent, has been shown to inhibit rotavirus.
Objective.
This double-blind, randomized trial was designed to study the role of nitazoxanide in acute rotavirus diarrhea.
Methods.
Of 174 children (12 months to 5 years) with acute diarrhea, 50 rotavirus positive cases were randomized.
The intervention group received syrup nitazoxanide twice daily (100 mg in 12–47 months, 200 mg in ≥4 yr) for 3 days along with standard treatment of diarrhea.
Duration of diarrhea was the primary outcome measure.
Results.
The median duration (hrs) of diarrhea (54 versus 80; 95% CI: –26 [–13.2 to –38.8]) and hospitalization (68 versus 90; 95% CI: –22 [–12.98 to –31.02]) was significantly shorter in the nitazoxanide group.
No significant difference was seen in the median duration (hrs) of fever or vomiting or the proportion of children requiring parenteral rehydration.
There was no report of any adverse events.
Conclusions.
Oral nitazoxanide is effective and safe in the management of acute rotavirus diarrhea in Indian children (CTRI REF/2016/10/012507).
American Psychological Association (APA)
Mahapatro, Samarendra& Mahilary, Nijwm& Satapathy, Amit Kumar& Das, Rashmi Ranjan. 2017. Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country. Journal of Tropical Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187949
Modern Language Association (MLA)
Mahapatro, Samarendra…[et al.]. Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country. Journal of Tropical Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1187949
American Medical Association (AMA)
Mahapatro, Samarendra& Mahilary, Nijwm& Satapathy, Amit Kumar& Das, Rashmi Ranjan. Nitazoxanide in Acute Rotavirus Diarrhea: A Randomized Control Trial from a Developing Country. Journal of Tropical Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1187949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187949