Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?
Joint Authors
Pimentel, Clebson Pantoja
Cortinhas-Alves, Erik Artur
de Oliveira, Edivaldo Herculano Correa
Santana-da-Silva, Luiz Carlos
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis.
The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis.
Method.
A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease.
Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing.
Results.
More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16.
Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis.
There was no difference between agenesis group and control group.
Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis.
Conclusion.
PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.
American Psychological Association (APA)
Pimentel, Clebson Pantoja& Cortinhas-Alves, Erik Artur& de Oliveira, Edivaldo Herculano Correa& Santana-da-Silva, Luiz Carlos. 2017. Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?. Journal of Thyroid Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1187963
Modern Language Association (MLA)
Pimentel, Clebson Pantoja…[et al.]. Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?. Journal of Thyroid Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1187963
American Medical Association (AMA)
Pimentel, Clebson Pantoja& Cortinhas-Alves, Erik Artur& de Oliveira, Edivaldo Herculano Correa& Santana-da-Silva, Luiz Carlos. Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?. Journal of Thyroid Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1187963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187963