18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study
Joint Authors
Valentini, Vincenzo
Tagliaferri, Luca
Repaci, Andrea
Farina, Eleonora
Monari, Fabio
Castellucci, Paolo
Romani, Fabrizio
Farina, Arianna
Rambaldi, Giuseppe Zanirato
Frezza, Giovanni
Mazzarotto, Renzo
Cammelli, Silvia
Autorino, Rosa
Deodato, Francesco
Macchia, Gabriella
Cilla, Savino
Fanti, Stefano
Morganti, Alessio Giuseppe
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
To evaluate the clinical response rate after a postoperative 18F-FDG PET/CT guided external beam radiotherapy (EBRT) in Iodine-refractory differentiated thyroid cancer.
Material and Methods.
Patients with thyroid cancer locally recurrent after total thyroidectomy plus metabolic radiotherapy and treated with radical EBRT were included.
Inclusion criteria were detectable thyroglobulin (Tg), negative postmetabolic radiotherapy whole body scintigraphy, and no surgical indications.
The pretreatment 18F-FDG PET/CT resulted positive in all cases (loggia, lymph nodes, and lung).
EBRT was delivered with IMRT-SIB technique.
A 18F-FDG PET/CT revaluation and Tg dosage were performed 3 months after the treatment.
Results.
Sixteen consecutive patients were included in this analysis (median follow-up: 6–44 months).
Post-EBRT 18F-FDG PET/CT showed CR in 43.7%, PR in 31.2%, SD in 25.0% patients, and PD due to lung metastases in 12.5%.
Overall response rate was 75.0% (CI 95%: 41.4–93.3%).
Tg levels decreased in 75.0% with a median Δ of 68.0%.
Two-year PFS and OS rates were 80.0% and 93.0%, respectively.
Acute G3 toxicity occurred in 18.7% and late G2 toxicity in 12.5%.
Conclusions.
18F-FDG PET/CT was useful in target definition for radiotherapy planning, identifying positive areas not detected with 131I scintigraphy.
IMRT based EBRT was feasible and our results encourage future prospective studies.
This clinical trial is registered with ID: NCT03191643.
American Psychological Association (APA)
Farina, Eleonora& Monari, Fabio& Castellucci, Paolo& Romani, Fabrizio& Repaci, Andrea& Farina, Arianna…[et al.]. 2017. 18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study. Journal of Thyroid Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187980
Modern Language Association (MLA)
Farina, Eleonora…[et al.]. 18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study. Journal of Thyroid Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1187980
American Medical Association (AMA)
Farina, Eleonora& Monari, Fabio& Castellucci, Paolo& Romani, Fabrizio& Repaci, Andrea& Farina, Arianna…[et al.]. 18F-FDG Pet-Guided External Beam Radiotherapy in Iodine-Refractory Differentiated Thyroid Cancer: A Pilot Study. Journal of Thyroid Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1187980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1187980