Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients
Joint Authors
Lim, Paik Seong
Jeng, Yachung
Wu, Ming Ying
Wu, Tsai-Kun
Chen, Chang-Hsu
Tseng, Tien-Yu
Chen, Hung Ping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Despite the continuous progression in dialysis medicine, mortality and the burden of cardiovascular disease (CVD) among hemodialysis patients are still substantial.
Substantial evidence suggests that proinflammatory (CD16+) monocytes contribute to the development of atherosclerosis.
A cohort of 136 stable hemodialysis patients (follow-up: 6.25 year) was assessed to investigate the association between the proportion of CD16+ monocytes for all-cause and CVD mortalities.
The CD16+ monocytes were associated with both mortalities after adjusting for a preexisting CVD history.
Compared to the reference group (CD16+ monocytes within [15.6–18.6], the first and second quartile), patients with CD16+ monocytes above the highest quartile level (>21.5) had an adjusted hazard ratio (HR) of 30.85 (95% confidence interval [CI]: 7.12–133.8) for CVD mortality and 5.28 (2.07–13.49) for all-cause mortality, and those with CD16+ monocytes below the lowest quartile ≤15.6), had significantly elevated death risks after 3.5-year follow-up (HR [95% CI]: 10.9 [2.42–48.96] and 4.38 [1.45–13.24] for CV and all-cause mortalities, respectively).
The hemodialysis patients with CD16+ monocyte level in a low but mostly covering normal range also portended a poor prognosis.
The findings shed some light for nephrologists on future prospects of early recognizing immune dysfunction and improving early intervention outcomes.
American Psychological Association (APA)
Jeng, Yachung& Lim, Paik Seong& Wu, Ming Ying& Tseng, Tien-Yu& Chen, Chang-Hsu& Chen, Hung Ping…[et al.]. 2017. Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188053
Modern Language Association (MLA)
Jeng, Yachung…[et al.]. Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188053
American Medical Association (AMA)
Jeng, Yachung& Lim, Paik Seong& Wu, Ming Ying& Tseng, Tien-Yu& Chen, Chang-Hsu& Chen, Hung Ping…[et al.]. Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188053