Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease
Joint Authors
Pisano, Calogera
Ricasoli, Alessandro
Ruvolo, Giovanni
Balistreri, Carmela Rita
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media.
Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression.
The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix.
On the other hand, several inflammatory pathways (including TGF-β, TLR-4 interferon-γ, chemokines, and interferon-γ) seem to be involved in the medial degeneration related to aged and dilated aorta.
This is an overview on thoracic aortic aneurysm as an emerging inflammatory disease.
American Psychological Association (APA)
Pisano, Calogera& Balistreri, Carmela Rita& Ricasoli, Alessandro& Ruvolo, Giovanni. 2017. Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188064
Modern Language Association (MLA)
Pisano, Calogera…[et al.]. Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188064
American Medical Association (AMA)
Pisano, Calogera& Balistreri, Carmela Rita& Ricasoli, Alessandro& Ruvolo, Giovanni. Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188064