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The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes
Joint Authors
Giannetti, Stefano
Serrano, Alessia
Donno, Claudia
Perić, Mina
D’Ambrosi, Nadia
Michetti, Fabrizio
Andjus, Pavle
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Neuroinflammation is one of the major players in amyotrophic lateral sclerosis (ALS) pathogenesis, and astrocytes are significantly involved in this process.
The astrocytic protein S100B can be released in pathological states activating the receptor for advanced glycation end products (RAGE).
Different indications point to an aberrant expression of S100B and RAGE in ALS.
In this work, we observed that S100B and RAGE are progressively and selectively upregulated in astrocytes of diseased rats with a tissue-specific timing pattern, correlated to the level of neurodegeneration.
The expression of the full-length and soluble RAGE isoforms could also be linked to the degree of tissue damage.
The mere presence of mutant SOD1 is able to increase the intracellular levels and release S100B from astrocytes, suggesting the possibility that an increased astrocytic S100B expression might be an early occurring event in the disease.
Finally, our findings indicate that the protein may exert a proinflammatory role in ALS, since its inhibition in astrocytes derived from SOD1G93A mice limits the expression of reactivity-linked/proinflammatory genes.
Thus, our results propose the S100B-RAGE axis as an effective contributor to the pathogenesis of the disease, suggesting its blockade as a rational target for a therapeutic intervention in ALS.
American Psychological Association (APA)
Serrano, Alessia& Donno, Claudia& Giannetti, Stefano& Perić, Mina& Andjus, Pavle& D’Ambrosi, Nadia…[et al.]. 2017. The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188098
Modern Language Association (MLA)
Serrano, Alessia…[et al.]. The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188098
American Medical Association (AMA)
Serrano, Alessia& Donno, Claudia& Giannetti, Stefano& Perić, Mina& Andjus, Pavle& D’Ambrosi, Nadia…[et al.]. The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188098