![](/images/graphics-bg.png)
Anti-TNF-Alpha-Adalimumab Therapy Had Time Lag of Improvement in Synovial Hypertrophy Compared to Rapid Response in Power Doppler Synovial Vascularity
Joint Authors
Chiu, Wen-Chan
Hsu, Chung-Yuan
Chen, Ying-Chou
Ko, Chi-Hua
Chen, Jia-Feng
Cheng, Tien-Tsai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
The quantification of synovitis is of great significance for follow-up in patients with rheumatoid arthritis (RA).
This study aimed to validate the use of power Doppler ultrasonography (PDUS) for evaluating synovial vascularity and synovial hypertrophy for synovitis in patients with rheumatoid arthritis treated with adalimumab.
Materials and Methods.
The synovial disease activity and vascularity of RA on both wrists (radio-carpal joint) were assessed using GS and PDUS to derive the composite US scores based on abnormal counts and severity.
The relationship between each measure was determined.
Results.
The 71 patients who received adalimumab therapy had significantly decreased DAS28, ESR, and CRP.
After one month, PD score decreased and then remained low for 12 months.
Synovial hypertrophy did not change until 3–6 months after, when it started to improve (p=0.017).
By multivariate analysis, sex, age, BMI, and DAS28 did not lead to any difference between synovial hypertrophy and PDUS changes (p=0.498).
Discussion.
Composite US markers of synovial hypertrophy correlate significantly to the DAS28 score and ESR/CRP in adult RA.
The time needed for synovial hypertrophy to decrease may be up to 3–6 months after adalimumab therapy.
Switching to biological therapy before 3–6 months is inappropriate and ineffective.
American Psychological Association (APA)
Chen, Ying-Chou& Ko, Chi-Hua& Chen, Jia-Feng& Hsu, Chung-Yuan& Chiu, Wen-Chan& Cheng, Tien-Tsai. 2017. Anti-TNF-Alpha-Adalimumab Therapy Had Time Lag of Improvement in Synovial Hypertrophy Compared to Rapid Response in Power Doppler Synovial Vascularity. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188107
Modern Language Association (MLA)
Chen, Ying-Chou…[et al.]. Anti-TNF-Alpha-Adalimumab Therapy Had Time Lag of Improvement in Synovial Hypertrophy Compared to Rapid Response in Power Doppler Synovial Vascularity. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188107
American Medical Association (AMA)
Chen, Ying-Chou& Ko, Chi-Hua& Chen, Jia-Feng& Hsu, Chung-Yuan& Chiu, Wen-Chan& Cheng, Tien-Tsai. Anti-TNF-Alpha-Adalimumab Therapy Had Time Lag of Improvement in Synovial Hypertrophy Compared to Rapid Response in Power Doppler Synovial Vascularity. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188107