Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects
Joint Authors
Moilanen, Eeva
Vuolteenaho, Katriina
Väänänen, Tuija
Hämäläinen, Mari
Lehtimäki, Lauri
Kankaanranta, Hannu
Vierikko, Tuula
Oksa, Panu
Järvenpää, Ritva
Uitti, Jukka
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis.
Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen production and fibrosis.
We studied if YKL-40 is related to inflammation, fibrosis, and/or lung function in subjects exposed to asbestosis.
Venous blood samples were collected from 85 men with moderate or heavy occupational asbestos exposure and from 28 healthy, age-matched controls.
Levels of plasma YKL-40, CRP, IL-6, adipsin, and MMP-9 were measured with enzyme-linked immunosorbent assay (ELISA).
Plasma YKL-40 levels were significantly higher in subjects with asbestosis (n=19) than in those with no fibrotic findings in HRCT following asbestos exposure (n=66) or in unexposed healthy controls.
In asbestos-exposed subjects, plasma YKL-40 correlated negatively with lung function capacity parameters FVC (Pearson’s r −0.259, p=0.018) and FEV1 (Pearson’s r −0.240, p=0.028) and positively with CRP (Spearman’s rho 0.371, p<0.001), IL-6 (Spearman’s rho 0.314, p=0.003), adipsin (Spearman’s rho 0.459, p<0.001), and MMP-9 (Spearman’s rho 0.243, p=0.025).
The present finding suggests YKL-40 as a biomarker associated with fibrosis and inflammation in asbestos-exposed subjects.
American Psychological Association (APA)
Väänänen, Tuija& Lehtimäki, Lauri& Vuolteenaho, Katriina& Hämäläinen, Mari& Oksa, Panu& Vierikko, Tuula…[et al.]. 2017. Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188122
Modern Language Association (MLA)
Väänänen, Tuija…[et al.]. Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188122
American Medical Association (AMA)
Väänänen, Tuija& Lehtimäki, Lauri& Vuolteenaho, Katriina& Hämäläinen, Mari& Oksa, Panu& Vierikko, Tuula…[et al.]. Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188122