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Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis
Joint Authors
Xu, JinFu
Fan, Lichao
Yu, Xiaoting
Huang, Ziling
Zheng, Shaoqiang
Zhou, Yongxin
Lv, Hanjing
Zeng, Yu
Zhu, Xuyou
Yi, Xianghua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to identify potential microRNAs and genes associated with idiopathic pulmonary fibrosis (IPF) through web-available microarrays.
The microRNA microarray dataset GSE32538 and the mRNA datasets GSE32537, GSE53845, and GSE10667 were downloaded from the Gene Expression Omnibus (GEO) database.
Differentially expressed miRNAs (DE-miRNAs)/genes (DEGs) were screened with GEO2R, and their associations with IPF were analyzed by comprehensive bioinformatic analyses.
A total of 45 DE-microRNAs were identified between IPF and control tissues, whereas 67 common DEGs were determined to exhibit the same expression trends in all three microarrays.
Furthermore, functional analysis indicated that microRNAs in cancer and ECM-receptor interaction were the most significant pathways and were enriched by the 45 DE-miRNAs and 67 common DEGs.
Finally, we predicted potential microRNA-target interactions between 17 DE-miRNAs and 17 DEGs by using at least three online programs.
A microRNA-mediated regulatory network among the DE-miRNAs and DEGs was constructed that might shed new light on potential biomarkers for the prediction of IPF progression.
American Psychological Association (APA)
Fan, Lichao& Yu, Xiaoting& Huang, Ziling& Zheng, Shaoqiang& Zhou, Yongxin& Lv, Hanjing…[et al.]. 2017. Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188123
Modern Language Association (MLA)
Fan, Lichao…[et al.]. Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188123
American Medical Association (AMA)
Fan, Lichao& Yu, Xiaoting& Huang, Ziling& Zheng, Shaoqiang& Zhou, Yongxin& Lv, Hanjing…[et al.]. Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188123