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Visfatin Triggers Anorexia and Body Weight Loss through Regulating the Inflammatory Response in the Hypothalamic Microglia
Joint Authors
Nam-Goong, Il Seong
Lee, Jisung
Yang, Sunggu
Kim, Jae Geun
Tu, Thai Hien
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Visfatin is an adipokine that is secreted from adipose tissue, and it is involved in a variety of physiological processes.
In particular, visfatin has been implicated in metabolic diseases, such as obesity and type 2 diabetes, which are directly linked to systemic inflammation.
However, the potential impacts of visfatin on the hypothalamic control of energy homeostasis, which is involved in microglial inflammation, have not fully been investigated.
In this study, we found that treatment with exogenous recombinant visfatin protein led to the activation of the inflammatory response in a microglial cell line.
In addition, we observed that central administration of visfatin led to the activation of microglia in the hypothalamus.
Finally, we found that visfatin reduced food intake and body weight through activating POMC neurons in association with microglia activation in mice.
These findings indicate that elevation of central visfatin levels may be associated with homeostatic feeding behavior in response to metabolic shifts, such as increased adiposity following inflammatory processes in the hypothalamus.
American Psychological Association (APA)
Tu, Thai Hien& Nam-Goong, Il Seong& Lee, Jisung& Yang, Sunggu& Kim, Jae Geun. 2017. Visfatin Triggers Anorexia and Body Weight Loss through Regulating the Inflammatory Response in the Hypothalamic Microglia. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188132
Modern Language Association (MLA)
Tu, Thai Hien…[et al.]. Visfatin Triggers Anorexia and Body Weight Loss through Regulating the Inflammatory Response in the Hypothalamic Microglia. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188132
American Medical Association (AMA)
Tu, Thai Hien& Nam-Goong, Il Seong& Lee, Jisung& Yang, Sunggu& Kim, Jae Geun. Visfatin Triggers Anorexia and Body Weight Loss through Regulating the Inflammatory Response in the Hypothalamic Microglia. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188132