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Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer
Joint Authors
Tsuchida, Junko
Takabe, Kazuaki
Wakai, Toshifumi
Nagahashi, Masayuki
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Breast cancer metastasizes to lymph nodes or other organs, which determine the prognosis of patients.
It is difficult to cure the breast cancer patients with distant metastasis due to resistance to drug therapies.
Elucidating the underlying mechanisms of breast cancer metastasis and drug resistance is expected to provide new therapeutic targets.
Sphingosine-1-phosphate (S1P) is a pleiotropic, bioactive lipid mediator that regulates many cellular functions, including proliferation, migration, survival, angiogenesis/lymphangiogenesis, and immune responses.
S1P is formed in cells by sphingosine kinases and released from them, which acts in an autocrine, paracrine, and/or endocrine manner.
S1P in extracellular space, such as interstitial fluid, interacts with components in the tumor microenvironment, which may be important for metastasis.
Importantly, recent translational research has demonstrated an association between S1P levels in breast cancer patients and clinical outcomes, highlighting the clinical importance of S1P in breast cancer.
We suggest that S1P is one of the key molecules to overcome the resistance to the drug therapies, such as hormonal therapy, anti-HER2 therapy, or chemotherapy, all of which are crucial aspects of a breast cancer treatment.
American Psychological Association (APA)
Tsuchida, Junko& Nagahashi, Masayuki& Takabe, Kazuaki& Wakai, Toshifumi. 2017. Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188139
Modern Language Association (MLA)
Tsuchida, Junko…[et al.]. Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188139
American Medical Association (AMA)
Tsuchida, Junko& Nagahashi, Masayuki& Takabe, Kazuaki& Wakai, Toshifumi. Clinical Impact of Sphingosine-1-Phosphate in Breast Cancer. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188139