Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis
Joint Authors
Bai, Yanping
Lu, Cheng
Niu, Xuyan
Qi, Qiu
Jiang, Chunyan
Wang, Yang
Zhou, Youwen
Lu, Ai-ping
Xiao, Cheng
Tan, Yong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Psoriasis (PS) and rheumatoid arthritis (RA) are immune-mediated inflammatory diseases.
Previous studies showed that these two diseases had a common pathogenesis, but the precise molecular mechanism remains unclear.
In this study, RNA sequencing of peripheral blood mononuclear cells was employed to explore both the differentially expressed genes (DEGs) of 10 PS and 10 RA patients compared with those of 10 healthy volunteers and the shared DEGs between these two diseases.
Bioinformatics network analysis was used to reveal the connections among the shared DEGs and the corresponding molecular mechanism.
In total, 120 and 212 DEGs were identified in PS and RA, respectively, and 31 shared DEGs were identified.
Bioinformatics analysis indicated that the cytokine imbalance relevant to key molecules (such as extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF), colony-stimulating factor 3 (CSF3), interleukin- (IL-) 6, and interferon gene (IFNG)) and canonical signaling pathways (such as the complement system, antigen presentation, macropinocytosis signaling, nuclear factor-kappa B (NF-κB) signaling, and IL-17 signaling) was responsible for the common comprehensive mechanism of PS and RA.
Our findings provide a better understanding of the pathogenesis of PS and RA, suggesting potential strategies for treating and preventing both diseases.
This study may also provide a new paradigm for illuminating the common pathogenesis of different diseases.
American Psychological Association (APA)
Tan, Yong& Qi, Qiu& Lu, Cheng& Niu, Xuyan& Bai, Yanping& Jiang, Chunyan…[et al.]. 2017. Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188150
Modern Language Association (MLA)
Tan, Yong…[et al.]. Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188150
American Medical Association (AMA)
Tan, Yong& Qi, Qiu& Lu, Cheng& Niu, Xuyan& Bai, Yanping& Jiang, Chunyan…[et al.]. Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188150