Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases
Joint Authors
Tremoli, Elena
Castiglioni, Laura
Sironi, Luigi
Colazzo, Francesca
Gelosa, Paolo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway.
Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders.
5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases.
Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease.
The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction.
American Psychological Association (APA)
Colazzo, Francesca& Gelosa, Paolo& Tremoli, Elena& Sironi, Luigi& Castiglioni, Laura. 2017. Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188154
Modern Language Association (MLA)
Colazzo, Francesca…[et al.]. Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188154
American Medical Association (AMA)
Colazzo, Francesca& Gelosa, Paolo& Tremoli, Elena& Sironi, Luigi& Castiglioni, Laura. Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188154