The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa
Joint Authors
Jiménez-Gallo, D.
de la Varga-Martínez, R.
Ossorio-García, L.
Albarrán-Planelles, C.
Rodríguez, C.
Linares-Barrios, M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To assess inflammatory serum markers including serum proinflammatory cytokines, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) according to the clinical inflammatory activity of patients with hidradenitis suppurativa (HS).
Patients and Methods.
Seventy-four patients with HS were studied based on the Hidradenitis Suppurativa-Physician Global Assessment (HS-PGA) score and Hurley staging system.
Proinflammatory cytokines were measured using a multiplex cytokine assay.
Twenty-two healthy volunteers were recruited.
Results.
Serum interleukin- (IL-) 6, IL-23, soluble tumour necrosis factor alpha (TNF-α) receptor I (sTNF-RI), CRP, and ESR were different in the patients with HS compared with those in the healthy controls (P<0.05).
The levels of IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17A, sTNF-RII, CRP, and ESR were significantly elevated according to inflammatory activity based on HS-PGA scores (r>0.25, P<0.05).
The levels of IL-6 (r=0.53, P<0.001), CRP (r=0.54, P<0.001), and ESR (r=0.60, P<0.001) were especially well correlated with clinical inflammatory activity based on HS-PGA scores.
The levels of IL-6, IL-8, sTNF-RI, sTNF-RII, CRP, and ESR were significantly elevated according to Hurley staging system.
Conclusions.
Serum proinflammatory cytokines, CRP, and ESR are increased in relation to the clinical inflammatory activity of patients with HS compared with healthy controls.
Serum IL-6, CRP, and ESR are effective biomarkers for evaluating the severity of HS.
American Psychological Association (APA)
Jiménez-Gallo, D.& de la Varga-Martínez, R.& Ossorio-García, L.& Albarrán-Planelles, C.& Rodríguez, C.& Linares-Barrios, M.. 2017. The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188158
Modern Language Association (MLA)
Jiménez-Gallo, D.…[et al.]. The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188158
American Medical Association (AMA)
Jiménez-Gallo, D.& de la Varga-Martínez, R.& Ossorio-García, L.& Albarrán-Planelles, C.& Rodríguez, C.& Linares-Barrios, M.. The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188158