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Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells
Joint Authors
Albi, Elisabetta
Lazzarini, Andrea
Cataldi, Samuela
Ambesi-Impiombato, Francesco Saverio
Beccari, T.
Codini, M.
Légeron, François-Pierre
Curcio, Francesco
Tasegian, Anna
Traina, Giovanna
Arcuri, Cataldo
Mecca, Carmen
Garcia-Gil, Mercedes
Fioretti, Bernard
Hunot, Stephane
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis.
Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected.
In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease.
Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity.
The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed.
American Psychological Association (APA)
Cataldi, Samuela& Arcuri, Cataldo& Hunot, Stephane& Légeron, François-Pierre& Mecca, Carmen& Garcia-Gil, Mercedes…[et al.]. 2017. Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188160
Modern Language Association (MLA)
Cataldi, Samuela…[et al.]. Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188160
American Medical Association (AMA)
Cataldi, Samuela& Arcuri, Cataldo& Hunot, Stephane& Légeron, François-Pierre& Mecca, Carmen& Garcia-Gil, Mercedes…[et al.]. Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188160