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Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis
Joint Authors
Hemshekhar, Mahadevappa
Anaparti, Vidyanand
Hitchon, Carol
Mookherjee, Neeloffer
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA).
However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined.
We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA.
Buprenorphine administration altered the expression of cytokines, IFN-γ, IL-6, and MMP-3, and oxidative markers, for example, iNOS, superoxide dismutase (SOD1), and catalase (CAT), in the CIA mice.
As buprenorphine is an analgesic, we further monitored the association of expression of these biomarkers with pain scores in a human cohort of early rheumatoid arthritis (RA).
Serum MMP-3 levels and blood mRNA expression of antioxidants sod1 and cat correlated with pain scores in the RA cohort.
We have demonstrated that administration of buprenorphine alters the expression of inflammatory and oxidative stress-related molecular markers in a murine model of CIA.
This caveat needs to be considered in animal experiments using buprenorphine as an analgesic, as it can be a confounding factor in murine studies used for prediction of response to therapy.
Furthermore, the antioxidant enzymes that showed an association with pain scores in the human cohort may be explored as biomarkers for pain in future studies.
American Psychological Association (APA)
Hemshekhar, Mahadevappa& Anaparti, Vidyanand& Hitchon, Carol& Mookherjee, Neeloffer. 2017. Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188166
Modern Language Association (MLA)
Hemshekhar, Mahadevappa…[et al.]. Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188166
American Medical Association (AMA)
Hemshekhar, Mahadevappa& Anaparti, Vidyanand& Hitchon, Carol& Mookherjee, Neeloffer. Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188166