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Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis.
Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of cell-cell junctions, release of sequestered growth factors (TGF-β and VEGF), activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility.
Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways.
Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis.
American Psychological Association (APA)
Kryczka, Jakub& Boncela, Joanna. 2017. Proteases Revisited: Roles and Therapeutic Implications in Fibrosis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188169
Modern Language Association (MLA)
Kryczka, Jakub& Boncela, Joanna. Proteases Revisited: Roles and Therapeutic Implications in Fibrosis. Mediators of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1188169
American Medical Association (AMA)
Kryczka, Jakub& Boncela, Joanna. Proteases Revisited: Roles and Therapeutic Implications in Fibrosis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1188169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188169