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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases
Joint Authors
Mimura, Toshihide
Araki, Yasuto
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autoimmune diseases are chronic inflammatory disorders caused by a loss of self-tolerance, which is characterized by the appearance of autoantibodies and/or autoreactive lymphocytes and the impaired suppressive function of regulatory T cells.
The pathogenesis of autoimmune diseases is extremely complex and remains largely unknown.
Recent advances indicate that environmental factors trigger autoimmune diseases in genetically predisposed individuals.
In addition, accumulating results have indicated a potential role of epigenetic mechanisms, such as histone modifications, in the development of autoimmune diseases.
Histone modifications regulate the chromatin states and gene transcription without any change in the DNA sequence, possibly resulting in phenotype alteration in several different cell types.
In this paper, we discuss the significant roles of histone modifications involved in the pathogenesis of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary biliary cirrhosis, and type 1 diabetes.
American Psychological Association (APA)
Araki, Yasuto& Mimura, Toshihide. 2017. The Histone Modification Code in the Pathogenesis of Autoimmune Diseases. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188175
Modern Language Association (MLA)
Araki, Yasuto& Mimura, Toshihide. The Histone Modification Code in the Pathogenesis of Autoimmune Diseases. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188175
American Medical Association (AMA)
Araki, Yasuto& Mimura, Toshihide. The Histone Modification Code in the Pathogenesis of Autoimmune Diseases. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188175