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Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model
Joint Authors
Angelis, Dimitrios
Delivoria-Papadopoulos, Maria
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Protein tyrosine phosphatases (PTPs) in conjunction with protein tyrosine kinases (PTKs) regulate cellular processes by posttranslational modifications of signal transduction proteins.
PTP nonreceptor type 1B (PTP-1B) is an enzyme of the PTP family.
We have previously shown that hypoxia induces an increase in activation of a class of nonreceptor PTK, the Src kinases.
In the present study, we investigated the changes that occur in the expression of PTP-1B in the cytosolic component of the brain of newborn piglets acutely after hypoxia as well as long term for up to 2 weeks.
Methods.
Newborn piglets were divided into groups: normoxia, hypoxia, hypoxia followed by 1 day and 15 days in FiO2 0.21, and hypoxia pretreated with Src kinase inhibitor PP2, prior to hypoxia followed by 1 day and 15 days.
Hypoxia was achieved by providing 7% FiO2 for 1 hour and PTP-1B expression was measured via immunoblotting.
Results.
PTP-1B increased posthypoxia by about 30% and persisted for 2 weeks while Src kinase inhibition attenuated the expected PTP-1B-increased expression.
Conclusions.
Our study suggests that Src kinase mediates a hypoxia-induced increased PTP-1B expression.
American Psychological Association (APA)
Angelis, Dimitrios& Delivoria-Papadopoulos, Maria. 2017. Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188191
Modern Language Association (MLA)
Angelis, Dimitrios& Delivoria-Papadopoulos, Maria. Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188191
American Medical Association (AMA)
Angelis, Dimitrios& Delivoria-Papadopoulos, Maria. Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188191