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Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions
Joint Authors
Sasiain, María del Carmen
Kviatcovsky, Denise
Rivadeneyra, Leonardo
Yokobori, Noemí
Schattner, Mirta
López, Beatriz
de la Barrera, Silvia S.
Ritacco, Viviana
Balboa, Luciana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
M strain, the most prevalent multidrug-resistant strain of Mycobacterium tuberculosis (Mtb) in Argentina, has mounted mechanisms to evade innate immune response.
The role of human bronchial epithelium in Mtb infection remains unknown as well as its crosstalk with neutrophils (PMN).
In this work, we evaluate whether M and H37Rv strains invade and replicate within bronchial epithelial cell line Calu-6 and how conditioned media (CM) derived from infected cells alter PMN responses.
We demonstrated that M infects and survives within Calu-6 without promoting death.
CM from M-infected Calu-6 (M-CM) did not attract PMN in correlation with its low IL-8 content compared to H37Rv-CM.
Also, PMN activation and ROS production in response to irradiated H37Rv were impaired after treatment with M-CM due to the lack of TNF-α.
Interestingly, M-CM increased H37Rv replication in PMN which would allow the spreading of mycobacteria upon PMN death and sustain IL-8 release.
Thus, our results indicate that even at low invasion/replication rate within Calu-6, M induces the secretion of factors altering the crosstalk between these nonphagocytic cells and PMN, representing an evasion mechanism developed by M strain to persist in the host.
These data provide new insights on the role of bronchial epithelium upon M infection.
American Psychological Association (APA)
Kviatcovsky, Denise& Rivadeneyra, Leonardo& Balboa, Luciana& Yokobori, Noemí& López, Beatriz& Ritacco, Viviana…[et al.]. 2017. Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188194
Modern Language Association (MLA)
Kviatcovsky, Denise…[et al.]. Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188194
American Medical Association (AMA)
Kviatcovsky, Denise& Rivadeneyra, Leonardo& Balboa, Luciana& Yokobori, Noemí& López, Beatriz& Ritacco, Viviana…[et al.]. Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF-α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188194