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Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis
Joint Authors
Liu, Qingjuan
Du, Yunxia
Li, Kejun
Zhang, Wei
Feng, Xiaojuan
Hao, Jun
Li, Hongbo
Liu, Shuxia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The purpose of this study was to investigate the role of oncostatin M (OSM) in tubulointerstitial lesion (TIL) in lupus nephritis (LN).
We found that OSM was highly expressed in the renal tissue of LN mice.
OSM is one of the interleukin-6 cytokine family members.
In order to clarify the role and mechanism of OSM in LN, mice with LN were treated with anti-OSM antibody or isotype antibody.
We evaluated the tubular epithelial-mesenchymal transdifferentiation (EMT) by detecting the E-cadherin, α-smooth muscle actin (α-SMA), and fibronectin (FN) expression.
We analyzed the inflammation by observing the monocyte chemotactic factor-1 (MCP-1) and intercellular adhesion molecule (ICAM-1) expression and calculated the tubulointerstitial fibrosis area by Masson staining.
The results showed that anti-OSM antibody, rather than isotype antibody, improved EMT, inflammation, and tubulointerstitial fibrosis.
In addition, the signal transducer and activator of transcription (STAT) 1 and STAT3 signaling was activated by tyrosine phosphorylation in LN mouse renal tissue, indicating that the phosphorylated STAT1 (p-STAT1) and p-STAT3 were involved in kidney injury.
Moreover, decreased p-STAT3 instead of p-STAT1 has been observed after anti-OSM antibody injection.
Thus, we concluded that OSM is associated with TIL in lupus nephritis, which may be connected with the activation of STAT3 rather than that of STAT1.
American Psychological Association (APA)
Liu, Qingjuan& Du, Yunxia& Li, Kejun& Zhang, Wei& Feng, Xiaojuan& Hao, Jun…[et al.]. 2017. Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188218
Modern Language Association (MLA)
Liu, Qingjuan…[et al.]. Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188218
American Medical Association (AMA)
Liu, Qingjuan& Du, Yunxia& Li, Kejun& Zhang, Wei& Feng, Xiaojuan& Hao, Jun…[et al.]. Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188218