Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics
Joint Authors
Milnerowicz, Halina
Ściskalska, Milena
Marek, Grzegorz
Grzebieniak, Zygmunt
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The study was aimed to assess the influence of tobacco smoke exposure on the intensity of inflammation measured by IL-6, α1-antitripsin (AAT) and α1-acid glycoprotein (AGP) concentrations, and Cd level and oxidative stress intensity measured by advanced oxidation protein product (AOPP) concentration in the blood of healthy subjects and AP patients during hospitalization.
Endothelin-1 (ET-1) and resistin concentrations, markers of endothelium injury, were determined.
Results.
An increased IL-6 concentration in healthy smokers compared to nonsmokers and AP patients compared to controls was shown.
An increased AAT and AGP concentrations during hospitalization of AP patients were noted, in both smokers (AAT, AGP) and nonsmokers (AAT).
In comparison to control groups, in AP patients, a 2-fold increased resistin concentration correlating with ET-1 concentration and decreased albumin concentration accompanied by increased AOPP concentration were demonstrated.
AOPP concentration was higher in smokers with AP compared to nonsmokers and gradually enhanced during their hospitalization.
Conclusions.
Tobacco smoke exposure can have a proinflammatory effect in both healthy subjects and AP patients.
Increased resistin concentration in AP patients negatively correlating with albumin concentration has prooxidative effect on this protein resulting in enhanced AOPP level.
Increased resistin concentration can intensify AAT and AGP production during AP.
American Psychological Association (APA)
Ściskalska, Milena& Marek, Grzegorz& Grzebieniak, Zygmunt& Milnerowicz, Halina. 2017. Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188220
Modern Language Association (MLA)
Ściskalska, Milena…[et al.]. Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188220
American Medical Association (AMA)
Ściskalska, Milena& Marek, Grzegorz& Grzebieniak, Zygmunt& Milnerowicz, Halina. Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188220