Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
Joint Authors
Macek Jilkova, Zuzana
Decaens, Thomas
Marlu, Alice
Marche, Hélène
Jouvin-Marche, Evelyne
Marche, Patrice N.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection.
Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n=125).
The frequency of CD107+ NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p=0.002) and correlated with the plasma levels of estradiol (correlation coefficient r=0.634; p<0.0001).
Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients.
This probably contributes to the ability of females to better deal with HBV disease.
American Psychological Association (APA)
Macek Jilkova, Zuzana& Decaens, Thomas& Marlu, Alice& Marche, Hélène& Jouvin-Marche, Evelyne& Marche, Patrice N.. 2017. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188236
Modern Language Association (MLA)
Macek Jilkova, Zuzana…[et al.]. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels. Mediators of Inflammation No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1188236
American Medical Association (AMA)
Macek Jilkova, Zuzana& Decaens, Thomas& Marlu, Alice& Marche, Hélène& Jouvin-Marche, Evelyne& Marche, Patrice N.. Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188236