Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis
Joint Authors
Nau, Julia
Däubener, Walter
Eller, Silvia K.
Spekker-Bosker, Katrin
Wenning, Johannes
Hotop, Andrea
Groß, Uwe
Schwerk, Christian
Schroten, Horst
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Porcine infections are currently not the state-of-the-art model to study human diseases.
Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis.
For example, severity of infection, transplacental transmission, and interferon-gamma-induced antiparasitic effector mechanisms are similar in pigs and humans.
In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones.
Thus, we hypothesise that porcine Toxoplasma gondii infection data are more representative for human toxoplasmosis.
We therefore suggest that the animal model chosen must be critically evaluated for its assignability to human diseases.
American Psychological Association (APA)
Nau, Julia& Eller, Silvia K.& Wenning, Johannes& Spekker-Bosker, Katrin& Schroten, Horst& Schwerk, Christian…[et al.]. 2017. Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188238
Modern Language Association (MLA)
Nau, Julia…[et al.]. Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188238
American Medical Association (AMA)
Nau, Julia& Eller, Silvia K.& Wenning, Johannes& Spekker-Bosker, Katrin& Schroten, Horst& Schwerk, Christian…[et al.]. Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188238