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A Protective Role of Glibenclamide in Inflammation-Associated Injury
Joint Authors
Pan, Chuli
Zhang, Gensheng
Lin, Xiuhui
Zhang, Shufang
Xiu, Huiqing
Cui, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glibenclamide is the most widely used sulfonylurea drug for the treatment of type 2 diabetes mellitus (DM).
Recent studies have suggested that glibenclamide reduced adverse neuroinflammation and improved behavioral outcomes following central nervous system (CNS) injury.
We reviewed glibenclamide’s anti-inflammatory effects: abundant evidences have shown that glibenclamide exerted an anti-inflammatory effect in respiratory, digestive, urological, cardiological, and CNS diseases, as well as in ischemia-reperfusion injury.
Glibenclamide might block KATP channel, Sur1-Trpm4 channel, and NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, decrease the production of proinflammatory mediators (TNF-α, IL-1β, and reactive oxygen species), and suppress the accumulation of inflammatory cells.
Glibenclamide’s anti-inflammation warrants further investigation.
American Psychological Association (APA)
Zhang, Gensheng& Lin, Xiuhui& Zhang, Shufang& Xiu, Huiqing& Pan, Chuli& Cui, Wei. 2017. A Protective Role of Glibenclamide in Inflammation-Associated Injury. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188268
Modern Language Association (MLA)
Zhang, Gensheng…[et al.]. A Protective Role of Glibenclamide in Inflammation-Associated Injury. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188268
American Medical Association (AMA)
Zhang, Gensheng& Lin, Xiuhui& Zhang, Shufang& Xiu, Huiqing& Pan, Chuli& Cui, Wei. A Protective Role of Glibenclamide in Inflammation-Associated Injury. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188268