![](/images/graphics-bg.png)
Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study
Joint Authors
Yu, Hui
Dong, Rui
Lu, Yayuan
Yang, Xi
Chen, Chang
Zhang, Zongze
Peng, Mian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Design.
A prospective cohort study.
Setting.
University medical centre.
Participants.
Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants.
Measurements.
The inflammatory marker levels in plasma and cognitive function were measured.
Results.
Twenty (39.2%, 20/51) patients developed POCD at 1 w after CRS-HIPEC.
The patients with POCD had higher serum interleukin 1β (IL-1β), serum amyloid A (SAA), S100 calcium-binding protein β (S-100β), and high mobility group box-1 protein (HMGB-1) levels at 1 and 24 h postoperatively than patients without POCD.
There was an association between POCD and the maximum IL-1β and S-100β concentrations in serum, which remained following adjustment for age and FBS.
Conclusion.
In this pilot study, perioperative inflammatory marker levels increase significantly after CRS-HIPEC in adult patients, and such elevations are associated with the development of short-term cognitive dysfunction after this complex surgery.
These results suggested the need for a larger RCT to replicate and confirm these findings.
American Psychological Association (APA)
Yu, Hui& Dong, Rui& Lu, Yayuan& Yang, Xi& Chen, Chang& Zhang, Zongze…[et al.]. 2017. Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188270
Modern Language Association (MLA)
Yu, Hui…[et al.]. Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188270
American Medical Association (AMA)
Yu, Hui& Dong, Rui& Lu, Yayuan& Yang, Xi& Chen, Chang& Zhang, Zongze…[et al.]. Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188270