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Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
Joint Authors
Portillo, María P.
Castañer, Olga
Corella, Dolores
Lamuela-Raventós, Rosa M.
Casas, Rosa
Urpi-Sardà, Mireia
Sacanella, Emilio
Arranz, Sara
Lapetra, José
Estruch, Ramón
Salas-Salvadó, Jordi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease.
Design and Setting.
66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD).
At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®.
Results.
At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD.
IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group.
Conclusions.
Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
American Psychological Association (APA)
Casas, Rosa& Urpi-Sardà, Mireia& Sacanella, Emilio& Arranz, Sara& Corella, Dolores& Castañer, Olga…[et al.]. 2017. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188280
Modern Language Association (MLA)
Casas, Rosa…[et al.]. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188280
American Medical Association (AMA)
Casas, Rosa& Urpi-Sardà, Mireia& Sacanella, Emilio& Arranz, Sara& Corella, Dolores& Castañer, Olga…[et al.]. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188280