Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses
Joint Authors
Shen, Xia
Zhao, Zhenyu
Wang, Hao
Hu, Benxiang
Guo, Zihu
Zhang, Gang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
This study was aimed at elucidating the molecular mechanisms underlying the anti-inflammatory effect of the combined application of Bupleuri Radix and Scutellariae Radix and explored the potential therapeutic efficacy of these two drugs on inflammation-related diseases.
Methods.
After searching the databases, we collected the active ingredients of Bupleuri Radix and Scutellariae Radix and calculated their oral bioavailability (OB) and drug-likeness (DL) based on the absorption-distribution-metabolism-elimination (ADME) model.
In addition, we predicted the drug targets of the selected active components based on weighted ensemble similarity (WES) and used them to construct a drug-target network.
Gene ontology (GO) analysis and KEGG mapper tools were performed on these predicted target genes.
Results.
We obtained 30 compounds from Bupleuri Radix and Scutellariae Radix of good quality as indicated by ADME assays, which possess potential pharmacological activity.
These 30 ingredients have a total of 121 potential target genes, which are involved in 24 biological processes related to inflammation.
Conclusions.
Combined application of Bupleuri Radix and Scutellariae Radix was found not only to directly inhibit the synthesis and release of inflammatory cytokines, but also to have potential therapeutic effects against inflammation-induced pain.
In addition, a combination therapy of these two drugs exhibited systemic treatment efficacy and provided a theoretical basis for the development of drugs against inflammatory diseases.
American Psychological Association (APA)
Shen, Xia& Zhao, Zhenyu& Wang, Hao& Guo, Zihu& Hu, Benxiang& Zhang, Gang. 2017. Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188292
Modern Language Association (MLA)
Shen, Xia…[et al.]. Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188292
American Medical Association (AMA)
Shen, Xia& Zhao, Zhenyu& Wang, Hao& Guo, Zihu& Hu, Benxiang& Zhang, Gang. Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188292