Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation
Joint Authors
Ortega-Ramírez, Audrey
Vega, Rosario
Soto, Enrique
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride.
Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues.
Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing.
This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.
American Psychological Association (APA)
Ortega-Ramírez, Audrey& Vega, Rosario& Soto, Enrique. 2017. Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1188293
Modern Language Association (MLA)
Ortega-Ramírez, Audrey…[et al.]. Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation. Mediators of Inflammation No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1188293
American Medical Association (AMA)
Ortega-Ramírez, Audrey& Vega, Rosario& Soto, Enrique. Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1188293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188293