Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits
Joint Authors
Fan, Jianglin
Liu, Enqi
Zhao, Sihai
Cheng, Daxing
Gao, Shoucui
Wang, Xiaojing
Li, Jiayan
Li, Lu
Ran, Linwu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels.
However, many CETP inhibitors have failed to achieve a clinical benefit despite raising HDL-C.
In the study, we generated transgenic (Tg) rabbits that overexpressed the human CETP gene to examine the influence of CETP on the development of atherosclerosis.
Both Tg rabbits and their non-Tg littermates were fed a high cholesterol diet for 16 weeks.
Plasma lipids and body weight were measured every 4 weeks.
Gross lesion areas of the aortic atherosclerosis along with lesional cellular components were quantitatively analyzed.
Overexpression of human CETP did not significantly alter the gross atherosclerotic lesion area, but the number of macrophages in lesions was significantly increased.
Overexpression of human CETP did not change the plasma levels of total cholesterol or low-density lipoprotein cholesterol but lowered plasma HDL-C and increased triglycerides.
These data revealed that human CETP may play an important role in the development of atherosclerosis mainly by decreasing HDL-C levels and increasing the accumulation of macrophage-derived foam cells.
American Psychological Association (APA)
Gao, Shoucui& Wang, Xiaojing& Cheng, Daxing& Li, Jiayan& Li, Lu& Ran, Linwu…[et al.]. 2017. Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188298
Modern Language Association (MLA)
Gao, Shoucui…[et al.]. Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188298
American Medical Association (AMA)
Gao, Shoucui& Wang, Xiaojing& Cheng, Daxing& Li, Jiayan& Li, Lu& Ran, Linwu…[et al.]. Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188298