Transcriptional Profiling at High Temporal Resolution Reveals Robust ImmuneInflammatory Responses during Rat Sciatic Nerve Recovery
Joint Authors
Xing, Lingyan
Cheng, Qiong
Zha, Guangbin
Yi, Sheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
After peripheral nerve injury, immune/inflammatory responses are triggered, which are critical for nerve regeneration.
Despite their importance, the underlying molecular changes in immune/inflammatory responses remain largely unknown.
In this study, we systematically analyzed differentially expressed genes in immune/inflammatory-related pathways at high temporal resolution and experimentally validated gene expression changes with RT-PCR following sciatic nerve crush in rats.
We found that immune/inflammatory reactions not only occur in the acute injury but also remained activated over two weeks after injury.
Detailed bioinformatic studies suggested that multiple immune/inflammatory pathways, including agranulocyte adhesion and diapedesis, granulocyte adhesion and diapedesis, IL-6 signaling, and IL-10 signaling, were sustained activated during nerve degeneration and regeneration.
Our current study expands our understanding of the molecular basis of altered immune/inflammatory-related pathways following injury and thus might offer the possibility of targeting related molecules as therapeutic intervention for peripheral nerve regeneration.
American Psychological Association (APA)
Xing, Lingyan& Cheng, Qiong& Zha, Guangbin& Yi, Sheng. 2017. Transcriptional Profiling at High Temporal Resolution Reveals Robust ImmuneInflammatory Responses during Rat Sciatic Nerve Recovery. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188301
Modern Language Association (MLA)
Xing, Lingyan…[et al.]. Transcriptional Profiling at High Temporal Resolution Reveals Robust ImmuneInflammatory Responses during Rat Sciatic Nerve Recovery. Mediators of Inflammation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1188301
American Medical Association (AMA)
Xing, Lingyan& Cheng, Qiong& Zha, Guangbin& Yi, Sheng. Transcriptional Profiling at High Temporal Resolution Reveals Robust ImmuneInflammatory Responses during Rat Sciatic Nerve Recovery. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1188301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188301