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Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals
Joint Authors
Malavolta, Marco
Pacetti, Deborah
Giacconi, Robertina
Balzano, Michele
Frega, Natale Giuseppe
Laura, Costarelli
Piacenza, Francesco
Basso, Andrea
Gagliardi, Riccardo
Mocchegiani, Eugenio
Provinciali, Mauro
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Epidemiological studies have linked high consumption of meat with major age-related diseases including cardiovascular diseases.
Abnormal postprandial increases in plasma lipids after a meat meal have been hypothesized among the pathogenetic mechanisms.
However, it is still unknown if the postprandial serum derived after a normal meat meal is able to affect endothelial function, and if the type of meat and the age of the donors are critical factors.
Here, we show the effects of postprandial sera derived from healthy adults and elderly volunteers who consumed meat meals on human coronary artery endothelial cell (HCAEC) oxidative stress, gene expression, DNA damage, and cellular senescence.
We observed that a single exposure to postprandial serum induces a slight increase in ROS that is associated with modulation of gene expression pathways related to oxidative stress response and metabolism.
The postprandial-induced increase in ROS is not associated with a measurable DNA oxidative damage.
However, repeated exposure to postprandial serum induces an acceleration of cellular senescence.
Taking into account the deleterious role of cellular senescence in age-related vascular diseases, the results suggest a new mechanism by which excessive meat consumption and time spent in postprandial state may affect health status during aging.
American Psychological Association (APA)
Laura, Costarelli& Giacconi, Robertina& Piacenza, Francesco& Basso, Andrea& Pacetti, Deborah& Balzano, Michele…[et al.]. 2017. Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188304
Modern Language Association (MLA)
Laura, Costarelli…[et al.]. Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188304
American Medical Association (AMA)
Laura, Costarelli& Giacconi, Robertina& Piacenza, Francesco& Basso, Andrea& Pacetti, Deborah& Balzano, Michele…[et al.]. Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188304