General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD
Joint Authors
Chen, Xiaoheng
Li, Hui long
Hu, Rui
Li, Lu
Wang, Xin
Ding, Zhiguo
Yizhou, Mei
Bei, He
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Autoimmune thyroid disease (AITD) shows the highest incidence among organ-specific autoimmune diseases and is the most common thyroid disease in humans, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT).
The susceptibility to autoimmune diseases is affected by increased autoantibody levels, susceptibility gene polymorphisms, environmental factors, and psychological factors, but the pathogenesis remains unclear.
Various cytokines and related genes encoding them play important roles in the development and progression of AITD.
CD152, an expression product of the CTLA-4 gene, downregulates T cell activation.
The A/A genotype polymorphism in the CT60 locus may reduce the production of thyroid autoantibodies.
The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT.
GD is an organ-specific autoimmune disease involving increased secretion of thyroid hormone, whereas HT may be associated with the destruction of thyroid gland tissue and hypothyroidism.
These two diseases exhibit similar pathogenesis but opposite trends in the clinical manifestations.
In this review, we focus on the structure and function of these cytokines and related genes in AITD, as well as the association of polymorphisms with susceptibility to GD and HT, and attempt to describe their differences in pathogenesis and clinical manifestations.
American Psychological Association (APA)
Chen, Xiaoheng& Yizhou, Mei& Bei, He& Li, Hui long& Wang, Xin& Hu, Rui…[et al.]. 2017. General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188308
Modern Language Association (MLA)
Chen, Xiaoheng…[et al.]. General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD. Mediators of Inflammation No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1188308
American Medical Association (AMA)
Chen, Xiaoheng& Yizhou, Mei& Bei, He& Li, Hui long& Wang, Xin& Hu, Rui…[et al.]. General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1188308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188308