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The Protective Effect of Cordycepin on D-GalactosamineLipopolysaccharide-Induced Acute Liver Injury
Joint Authors
Wang, Fengzhong
Li, Jin
Zhong, Liping
Zhu, Haibo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
As the major active ingredient of Cordyceps militaris, cordycepin (3′-deoxyadenosine) has been well documented to alleviate inflammation and oxidative stress both in vitro and in vivo.
To explore the potential protective effect of cordycepin in fulminant hepatic failure, mice were pretreated with cordycepin for 3 weeks followed by D-galactosamine (GalN)/lipopolysaccharide (LPS) injection.
Then we found cordycepin (200 mg/kg) administration elevated survival rate, improved liver function, and suppressed hepatocyte apoptosis and necrosis in mice with severe hepatic damage by GalN/LPS treatment.
Further, cordycepin inhibited hepatic neutrophil and macrophage infiltration and prevented proinflammatory cytokine production possibly through suppressing TLR4 and NF-κB signaling transduction.
The blockade of reactive oxygen species (ROS) and lipid peroxidation production by cordycepin was associated with the decrease of NAD(P)H oxidase (NOX) activity.
Besides, cordycepin significantly prevented excessive autophagy induced by GalN/LPS in the liver.
These data suggested that cordycepin could be a promising therapeutic agent for GalN/LPS-induced hepatotoxicity.
American Psychological Association (APA)
Li, Jin& Zhong, Liping& Zhu, Haibo& Wang, Fengzhong. 2017. The Protective Effect of Cordycepin on D-GalactosamineLipopolysaccharide-Induced Acute Liver Injury. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188311
Modern Language Association (MLA)
Li, Jin…[et al.]. The Protective Effect of Cordycepin on D-GalactosamineLipopolysaccharide-Induced Acute Liver Injury. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188311
American Medical Association (AMA)
Li, Jin& Zhong, Liping& Zhu, Haibo& Wang, Fengzhong. The Protective Effect of Cordycepin on D-GalactosamineLipopolysaccharide-Induced Acute Liver Injury. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188311