The Role of PDGFs and PDGFRs in Colorectal Cancer
Joint Authors
Balacescu, Ovidiu
Balacescu, Loredana
Lisencu, Cosmin
Manzat Saplacan, Roberta M.
Gherman, Claudia
Chira, Romeo I.
Craiu, Anca
Mircea, Petru A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide.
Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis.
Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge.
The aim of our study is to point out the diagnosis and prediction role of PDGF family and their receptors in colorectal carcinogenesis.
Material and Methods.
A systematic search in Medline and PubMed for studies reporting the role of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in tumor biology related to CRC was made.
Results.
PDGFs are important growth factors for normal tissue growth and division, with an important role in blood vessel formation.
PDGFs/PDGFRs signaling pathway has been demonstrated to be involved in angiogenesis mainly by targeting pericytes and vascular smooth muscle cells.
High levels of PDGF-BB were reported in CRC patients compared to those with adenomas, while elevated levels of PDGFR α/β in the stroma of CRC patients were correlated with invasion and metastasis.
Moreover, PDGF-AB and PDGF-C were correlated with early diagnosis, cancer grading, and metastatic disease.
Conclusions.
Both PDGFs and PDGFRs families play an important role in colorectal carcinogenesis and could be considered to be investigated as useful biomarkers both for diagnosis and treatment of CRC.
American Psychological Association (APA)
Manzat Saplacan, Roberta M.& Balacescu, Loredana& Gherman, Claudia& Chira, Romeo I.& Craiu, Anca& Mircea, Petru A.…[et al.]. 2017. The Role of PDGFs and PDGFRs in Colorectal Cancer. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188335
Modern Language Association (MLA)
Manzat Saplacan, Roberta M.…[et al.]. The Role of PDGFs and PDGFRs in Colorectal Cancer. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188335
American Medical Association (AMA)
Manzat Saplacan, Roberta M.& Balacescu, Loredana& Gherman, Claudia& Chira, Romeo I.& Craiu, Anca& Mircea, Petru A.…[et al.]. The Role of PDGFs and PDGFRs in Colorectal Cancer. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188335