Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases
Joint Authors
Santiago, Ana R.
Ambrósio, António F.
Madeira, Maria H.
Boia, Raquel
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Caffeine is the major component of coffee and the most consumed psychostimulant in the world and at nontoxic doses acts as a nonselective adenosine receptor antagonist.
Epidemiological evidence suggests that caffeine consumption reduces the risk of several neurological and neurodegenerative diseases.
However, despite the beneficial effects of caffeine consumption in human health and behaviour, the mechanisms by which it impacts the pathophysiology of neurodegenerative diseases still remain to be clarified.
A promising hypothesis is that caffeine controls microglia-mediated neuroinflammatory response associated with the majority of neurodegenerative conditions.
Accordingly, it has been already described that the modulation of adenosine receptors, namely, the A2A receptor, affords neuroprotection through the control of microglia reactivity and neuroinflammation.
In this review, we will summarize the main effects of caffeine in the modulation of neuroinflammation in neurodegenerative diseases.
American Psychological Association (APA)
Madeira, Maria H.& Boia, Raquel& Ambrósio, António F.& Santiago, Ana R.. 2017. Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188338
Modern Language Association (MLA)
Madeira, Maria H.…[et al.]. Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases. Mediators of Inflammation No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1188338
American Medical Association (AMA)
Madeira, Maria H.& Boia, Raquel& Ambrósio, António F.& Santiago, Ana R.. Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1188338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188338