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Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo
Joint Authors
Deschner, James
Cirelli, Joni Augusto
Jäger, Andreas
Damanaki, Anna
Götz, Werner
Memmert, S.
Zhou, Xiaoyan
Nanayakkara, Shanika
Nokhbehsaim, Marjan
Eick, Sigrun
Nogueira, Andressa Vilas Boas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis.
This study sought to analyze the expression of the functional receptor for ghrelin (GHS-R1a) in periodontal cells and tissues under microbial conditions in vitro and in vivo.
The GHS-R1a expression in human periodontal cells challenged with the periodontopathogen Fusobacterium nucleatum, in gingival biopsies from periodontally healthy and diseased individuals, and from rats with and without ligature-induced periodontitis was analyzed by real-time PCR, immunocytochemistry, and immunofluorescence.
F.
nucleatum induced an initial upregulation and subsequent downregulation of GHS-R1a in periodontal cells.
In rat experimental periodontitis, the GHS-R1a expression at periodontitis sites was increased during the early stage of periodontitis, but significantly reduced afterwards, when compared with healthy sites.
In human gingival biopsies, periodontally diseased sites showed a significantly lower GHS-R1a expression than the healthy sites.
The expression of the functional ghrelin receptor in periodontal cells and tissues is modulated by periodontal bacteria.
Due to the downregulation of the functional ghrelin receptor by long-term exposure to periodontal bacteria, the anti-inflammatory actions of ghrelin may be diminished in chronic periodontal infections, which could lead to an enhanced periodontal inflammation and tissue destruction.
American Psychological Association (APA)
Nokhbehsaim, Marjan& Damanaki, Anna& Nogueira, Andressa Vilas Boas& Eick, Sigrun& Memmert, S.& Zhou, Xiaoyan…[et al.]. 2017. Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188360
Modern Language Association (MLA)
Nokhbehsaim, Marjan…[et al.]. Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188360
American Medical Association (AMA)
Nokhbehsaim, Marjan& Damanaki, Anna& Nogueira, Andressa Vilas Boas& Eick, Sigrun& Memmert, S.& Zhou, Xiaoyan…[et al.]. Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188360