Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases
Joint Authors
Carniglia, Lila
Ramírez, Delia
Durand, Daniela
Saba, Julieta
Turati, Juan
Caruso, Carla
Scimonelli, Teresa N.
Lasaga, Mercedes
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-05
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Microglial cells are responsible for immune surveillance within the CNS.
They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response.
This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response.
Alterations to this delicate process may lead to tissue damage, neuroinflammation, and neurodegeneration.
Chronic pain, such as inflammatory or neuropathic pain, is accompanied by neuroimmune activation, and the role of glial cells in the initiation and maintenance of chronic pain has been the subject of increasing research over the last two decades.
Neuropeptides are small amino acidic molecules with the ability to regulate neuronal activity and thereby affect various functions such as thermoregulation, reproductive behavior, food and water intake, and circadian rhythms.
Neuropeptides can also affect inflammatory responses and pain sensitivity by modulating the activity of glial cells.
The last decade has witnessed growing interest in the study of microglial activation and its modulation by neuropeptides in the hope of developing new therapeutics for treating neurodegenerative diseases and chronic pain.
This review summarizes the current literature on the way in which several neuropeptides modulate microglial activity and response to tissue damage and how this modulation may affect pain sensitivity.
American Psychological Association (APA)
Carniglia, Lila& Ramírez, Delia& Durand, Daniela& Saba, Julieta& Turati, Juan& Caruso, Carla…[et al.]. 2017. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1188383
Modern Language Association (MLA)
Carniglia, Lila…[et al.]. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators of Inflammation No. 2017 (2017), pp.1-23.
https://search.emarefa.net/detail/BIM-1188383
American Medical Association (AMA)
Carniglia, Lila& Ramírez, Delia& Durand, Daniela& Saba, Julieta& Turati, Juan& Caruso, Carla…[et al.]. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1188383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188383