Preparation of Encapsulated Resveratrol Liposome Thermosensitive Gel and Evaluation of Its Capability to Repair Sciatic Nerve Injury in Rats
Joint Authors
Lu, Hao
Yao, Hui
Zou, Rong
Chen, Xiwen
Xu, Hanlin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The purpose of this study was to prepare a liposomal temperature-sensitive gel able to slowly release resveratrol after local intramuscular injection.
The best formulation of resveratrol liposomes was based on the highest encapsulation efficiency and drug loading designed by Box-Behnken.
The prepared liposomes were approximately circular, with a mean particle diameter of 161.5±0.12 nm and zeta potential of -6.9 mV.
The optimized liposomes were dispersed in a polymer gel (PLGA-PEG-PLGA) for preparation of an in situ-formed gel at 35±2°C.
In vitro release of the prepared liposome temperature-sensitive gel was studied and compared with ordinary drug-releasing gels, revealing a significantly longer drug release time.
Finally, a rat sciatic nerve injury model was used to evaluate the pharmacological activity of the liposome temperature-sensitive gels for the repair of damaged nerves.
The results indicate that the gel was able to promote recovery of damaged nerves.
American Psychological Association (APA)
Yao, Hui& Lu, Hao& Zou, Rong& Chen, Xiwen& Xu, Hanlin. 2020. Preparation of Encapsulated Resveratrol Liposome Thermosensitive Gel and Evaluation of Its Capability to Repair Sciatic Nerve Injury in Rats. Journal of Nanomaterials،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1188384
Modern Language Association (MLA)
Yao, Hui…[et al.]. Preparation of Encapsulated Resveratrol Liposome Thermosensitive Gel and Evaluation of Its Capability to Repair Sciatic Nerve Injury in Rats. Journal of Nanomaterials No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1188384
American Medical Association (AMA)
Yao, Hui& Lu, Hao& Zou, Rong& Chen, Xiwen& Xu, Hanlin. Preparation of Encapsulated Resveratrol Liposome Thermosensitive Gel and Evaluation of Its Capability to Repair Sciatic Nerve Injury in Rats. Journal of Nanomaterials. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1188384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188384