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Skin Immune Landscape: Inside and Outside the Organism
Joint Authors
Pichon, C.
Abdallah, Florence
Mijouin, Lily
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The skin is an essential organ to the human body protecting it from external aggressions and pathogens.
Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a highly sophisticated compound known as the “skin immune system” (SIS).
Studies of skin immune sentinels provided essential insights of a complex and dynamic immunity, which was achieved through interaction between the external and internal cutaneous compartments.
In fact, the skin surface is cohabited by microorganisms recognized as skin microbiota that live in complete harmony with the immune sentinels and contribute to the epithelial barrier reinforcement.
However, under stress, the symbiotic relationship changes into a dysbiotic one resulting in skin disorders.
Hence, the skin microbiota may have either positive or negative influence on the immune system.
This review aims at providing basic background information on the cutaneous immune system from major cellular and molecular players and the impact of its microbiota on the well-coordinated immune responses in host defense.
American Psychological Association (APA)
Abdallah, Florence& Mijouin, Lily& Pichon, C.. 2017. Skin Immune Landscape: Inside and Outside the Organism. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188386
Modern Language Association (MLA)
Abdallah, Florence…[et al.]. Skin Immune Landscape: Inside and Outside the Organism. Mediators of Inflammation No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1188386
American Medical Association (AMA)
Abdallah, Florence& Mijouin, Lily& Pichon, C.. Skin Immune Landscape: Inside and Outside the Organism. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1188386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188386